Exploring Biomolecular Sequence ↔ Structure ↔ Function Relationships, II: A Primer on Comparative Sequence and Structure Analysis, and Molecular Visualization in PYMOL

What is the protein data bank (PDB)? The PDB archive is a repository of atomic coordinates and other information describing proteins, nucleic acids, and other important biological macromolecules and assemblies. Biochemists and structural biologists use methods such as X-ray crystallography, NMR spectroscopy, and cryo-electron microscopy to determine the location of each atom relative to each other in the molecule. This is known as ‘the 3D structure’ of the biomolecule. They then deposit this information, which is then annotated and publicly released into the archive by the wwPDB.